Molecular Formula | C22H27N3O5 |
Molar Mass | 413.47 |
Melting Point | 181-183°C |
Appearance | neat |
Merck | 7384 |
BRN | 3900576 |
pKa | pKa 1.96/8.08(H2O,t =15) (Uncertain) |
Storage Condition | 2-8℃ |
MDL | MFCD00135659 |
Hazard Symbols | T+ - Very toxic |
Risk Codes | 26/28 - Very toxic by inhalation and if swallowed. |
Safety Description | S25 - Avoid contact with eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | UN 1544 6.1/PG 1 |
WGK Germany | 3 |
RTECS | TJ2450000 |
HS Code | 2939800000 |
Hazard Class | 6.1(a) |
Packing Group | II |
Toxicity | LD50 i.p. in mice: 0.64 mg/kg (Sofia, Knabloch) |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
biological activity | Physostigmine salicylate (ethine salicylate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine salicyl can penetrate the blood-brain barrier and stimulate central cholinergic neurotransmission. Physostigmine salicyl can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine salicylate is also an antidote for anticholinergic intoxication. |
Animal Model: | Heterozygous transgenic mice (Tg(+) mice) |
Dosage: | 0.03, 0.1, and 0.3 mg/kg |
Administration: | SC; daily for 6 weeks |
Result: | Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals. |
Use | is an ophthalmic medication for the treatment of primary angle-closure glaucoma, occasionally primary open-angle glaucoma. |